Rev 16:4

4 The third poured out his bowl into the rivers and springs of water, and it became blood.

into the rivers and spring of waters and they became blood – as we discussed in Rev 14:6, the rivers and springs of water throughout the Bible and especially in the Gospel of John, and Revelation, refer to the holy spirit. Those in the kingdom of the beast will not be drinking the holy spirit, but a very unholy spirit.