Rev 17:2

2 with whom the kings of the earth committed sexual immorality, and those who dwell in the earth were made drunken with the wine of her sexual immorality.”

the kings of the earth committed fornication – the political fornication of the Church with the kings of the earth began as early as 150 AD, with “apologies” of doctrine made to the Emperor and the Roman senate. The rejection of the Catholic Church during the Reformation ended the “political relationships” that kept the saints under the power of Rome. The Reformation resulted in the separation of Church and State.

the inhabitants of the earth were drunk with the wine of her fornication – with the false religion of the beast. This drunkenness was first described in Isaiah 28:1, the “drunkards of Ephraim,” who became drunk with a corrupted religion.